Intensive Weight Loss Program Improves Physical Function in Older Obese Adults with Knee Osteoarthritis

Miller GD, Nicklas BJ, Davis C, Loeser RF, Lenchik L, and Messier SP. Obesity. 2006;14:1219-1230.

Objective

To assess the effect of an intensive weight loss program with a maximum of two meal replacements per day (shakes and bars) and a low-fat weekly menu plan on physical function and body composition in older obese adults with knee osteoarthritis (OA).

Methods

Eighty-seven older (60+) obese adults (BMI>30.0 kg/mm2) with knee OA were recruited for a 6-month trial. Participants were categorized randomly into one of two groups, a weight loss (WL; n=44) or a weight stable (WS; n=43) program. The WL participants were prescribed a 1000 kcal/d energy deficit diet with exercise 3 days a week, and the WS participants attended health sessions. Physical function which included a 6-minute walking distance and stair climb time, and body composition were assessed at baseline and six months.

Results

Body fat and fat-free mass were lower for the WL group (8.7+/-0.8%) compared to the WS group (0.0+/-0.7%) at 6 months. The WL group had greater 6-minute walk distance, and faster stair climb time than the WS group.

Conclusion

An intensive weight loss intervention using a reduced-calorie diet with Slim-Fast meal replacements and exercise training improves physical function in older obese adults with knee OA.

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