Effects of Maintained Weight Loss on Sleep Dynamics and Neck Morphology in Severely Obese Adults
Hernandez TL, Ballard RD, Weil KM, et al. Obesity. 2008;17:84-91.
Objective
To determine if moderate weight loss in severely obese adults resulted in reduction in apnea/hypopnea index, improved pharyngeal patency, reduced total body oxygen consumption and carbon dioxide production during sleep, and improved sleep quality
Methods
Fourteen morbidly obese (BMI >40kg/m2) subjects (3 males and 11 females), between 18 and 50 years of age, completed a controlled weight reduction program. This included 3 months of a weight loss program using Slim-Fast meal replacement products and 3 months of weight maintenance, where subjects were allowed two mixed-food meals daily with additional Slim-Fast meal replacement products to meet their daily caloric intake determined by a registered dietitian.
Results
The subjects’ mean weight was reduced from 134.0 ± 6.6 kg to 117.7±6.1 kg by the 17th day. Sleep efficiency and sleep quality improved with weight loss, but was not found to be significant. Weight loss did not lead to improvements in neck morphology.
Conclusion
With weight loss, comes improved nocturnal oxygen saturation and a reduced total work during sleep. Modest weight loss can benefit the morbidly obese, preventing further serious complications of Obstructive Sleep Apnea and sleep dynamics.
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