Is there one single obesity gene? Not likely, according to new research in the online journal BMC GENETICS. Researchers from the Monell Center found over 6,000 genes (about 25% of the genome) that help determine an individual’s body weight. To obtain an estimate of how many genes could potentially affect body weight, researchers surveyed the Jackson Laboratory Mouse Genome Database for information on body weights of knockout mouse strains. Knockout mice have had a specific gene inactivated, or “knocked out.” The Monell survey revealed that body weight was altered in over a third of the viable knockout strains. Thirty-one percent weighed less than controls (indicating that the missing genes contribute to heavier body weight), while another 3% weighed more (contributing to lighter weight).

Source:
MedicalNews Today
(January 15, 2008)

A new study suggests the risk of developing type 2 diabetes is influenced by the amount of fat a person accumulates in relation to their body size as they grow into adulthood -- not birth size or growth. Investigators found that an individual’s fat mass in adulthood was the only factor significantly related to insulin sensitivity. Published in Journal of Clinical Endocrinology and Metabolism (February 2008), the study looked at size at birth, adult body size and insulin-sensitivity in young adults. The study was conducted by researchers at Erasmus Medical Centre-Sophia, Children’s Hospital, Rotterdam, the Netherlands.

Source:
Reuters Health (March 6, 2008)

University of Michigan scientists conclude that abdominal fat may be worse for the heart than subcutaneous fat (which sits directly under the skin). The reasons are twofold: abdominal fat appears to boost inflammation and is linked to more severe atherosclerosis (hardening of the arteries), which makes heart attacks more likely. The study was published in Circulation (January 22, 2008).

Source:
WebMD Medical News (January 29, 2008)